Chimaeric HBV core particles carrying a defined segment of Puumala hantavirus nucleocapsid protein evoke protective immunity in an animal model.

The authors kindly provided us with accession number used in the design of the peptides. Protection was measured as lack of N antigen expression in the lungs and lack of anti-glycoprotein 2 antibody and of neutralizing antibodies response 21 days after puumala virus challenge(10^4 ID50) of epitope immunized mice.