Systems genetics identifies a macrophage cholesterol network that associates with physiological wound healing
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
We generated a genomic and phenotypic resource comprising genetically outbred mice in which we measured (i) quantitative differences in wound healing indicated as ear area (ii) bone marrow derived macrophage (BMDM) mRNA expression by RNA-sequencing (RNA-seq), (iii) genome-wide SNPs genotyping by low-coverage sequencing.We performed gene co-expression network analysis and we identified a network in macrophages enriched in cholesterol genes which is genetically controlled by Runx2 gene. In vivo pharmacological blockage of Fasn with cerulenin showed delayed wound healing in rats and increased macrophage recruitment to the wound.
提供机构：
Duke-NUS Medical School
创建时间：
2022-02-20
