A protein corona-based diagnostic tool for eroded atherosclerotic plaques: Proteome dataset.

This dataset refers to an experimental project for the development nanotechnology tool for the diagnosis of atherosclerosis of superficial erosion. The experimental procedures for mimicking superficial erosion involves two surgeries: first a cauterization of the left carotid artery is promoted (Electrical injury group). Then, 28 days after the first procedure, a second surgery is performed for the insertion of a constrictive cuff. These two procedures were controlled by a SHAM group, for cauterization group (Electrical injury group), and a non-constrictive cuff, for constricted cuff group. Unfractionated plasma of C57BL/6 APOE-/- mice of all groups were incubated with Fe-MOF and Zr-MOF nanoparticles for protein corona formation. Then, the protein corona were eluted and proteome analyzed. Proteomes of protein corona nanoparticles were compared with unfractionated plasma of each group.