Data from: Transcriptome analyses reveal genes and pathways associated with fatty acid composition traits in pigs

Fatty acid composition is associated with meat quality in pigs as well as
with obesity- and diabetes-related traits in humans. Liver and muscle are
important tissues for fatty acid metabolism. In this study, we evaluated
correlations between liver and muscle transcriptomes and fatty acid
composition traits in muscle and abdominal fat tissues in 335 F2 pigs from
a White Duroc × Erhualian F2 pig resource population. Transcripts
significantly correlated with fatty acid composition traits were enriched
for genes involved in the categories of triglyceride catabolic process,
mitochondrial function, hematological and immune system, and disease such
as Type II diabetes. Gene co-expression network analysis further
identified liver network modules relevant to fatty acid unsaturation index
that were enriched in platelet activation and the type I interferon
signaling pathway and highlighted the connections between variations in
fatty acid composition and genes involved in hematological and immune
system. Integrative analysis of the expression QTL identified ELOVL6 and
SCD as plausible candidate genes underlying the loci for muscle
C18:1n-9/C16:1n-7 values on chromosome 8 and the loci for muscle
C18:1n-9/C18:0 contents on chromosome 14 respectively.