Biochemical Mechanisms Supporting the Use of Polylaminin During Long-Duration Spaceflight

Long-duration human spaceflight exposes astronauts to progressive neurodegeneration, skeletal muscle atrophy, bone demineralization, mitochondrial dysfunction, and impaired tissue regeneration despite current countermeasures. This Perspective proposes polymerized laminin (polylaminin), an extracellular matrix biomaterial originally developed for neural regeneration, as a potential multifunctional regenerative platform for aerospace medicine. Based on its established biological roles in neuronal survival, neuromuscular junction stability, satellite-cell regulation, extracellular matrix organization, and tissue remodeling, we hypothesize that polylaminin may complement existing countermeasures by preserving structural cell–matrix communication during prolonged microgravity. Although no experimental evidence currently demonstrates efficacy in spaceflight physiology, the convergence between extracellular matrix biology and the mechanisms underlying space-induced degeneration provides a strong theoretical rationale for future translational investigation.