Data for DIME analysis repository

Data needed to produce figures and analysis for the manuscript analysing the <i>D</i>ietary B<i>I</i>oactives and <i>M</i>icrobiome Div<i>E</i>rsity (DIME) Analysis. Dietary bioactives have been associated with positive health effects such as cardiovascular health, or having anti-diabetic properties. Many bioactive compounds survive digestion arriving in the colon, where the gut microbiome can further metabolise them to forms more available to the host. Previous work has shown diets such as the Mediterranean diet, enriched in plant bioactives, affecting the composition and diversity of the gut microbiome. However, it is unclear which factors in such whole diet interventions underlie these changes, such as the bioactives themselves, the percentage of dietary fibres or macronutrient composition. In the Dietary BIoactives and Microbiome DivErsity (DIME) study we investigated the impact of a diet rich in a wide range of plant bioactives compared to a low bioactive diet with matched total fibre intake.Design: We conducted a randomised crossover intervention trial to assess alterations to the gut microbiome, urinary and faecal metabolites in 20 healthy subjects receiving two-week high- or low- bioactive diets, separated by a 4-week washout period. Macronutrient and total fibre content was carefully matched between diets.