Palladium-Catalyzed Highly Diastereoselective Oxidative Cascade Cyclization Reactions
收藏NIAID Data Ecosystem2026-03-06 收录
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Isoquinoline and quinoline have been discovered as novel ligands for palladium-catalyzed oxidative cascade cyclization reactions. With our new catalyst systems (Pd(OAc)2/isoquinoline or quinoline), unsaturated anilides cyclize under an oxygen atmosphere (1 atm) to furnish structurally versatile indoline derivatives in good yields. One C−N bond and two C−C bonds are formed in a single step with excellent diastereoselectivities (dr > 24:1).
创建时间：
2016-02-26
