Single cell transcriptome of human intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy within the liver, with a high degree of tumor heterogeneity and a very poor prognosis. In this study, single-cell transcriptome sequencing analysis was performed on 3 samples (1 plasma, 1 tumor and 1 paracancerous tissue) from an ICC patient with the aim of studying cell type variations in different tissue types. Overall design: To investigate the distribution of bacterial transcription products in various cell types, we analyzed ICC scRNA-seq data. In this study, we obtained single cell RNA-seq data from a total of 3 tissue samples (1 tumor tissue, 1 paracancer tissue and 1 plasma tissue) from 1 ICC patient, yielding a total of 11357 cells for subsequent clustering analysis.