BG-P400TAT, A Dual Targeting of Norepinephrine Transporter Function and Thyrointegrin αvβ3 receptors to Treat Neuroblastoma cancer

To explore molecular mechanisms of anti-cancer activities of BG-P400-TAT, genome-wide expression profiling experiments were carried out . Human neuroblastoma SKNAS cells were treated with 30µM of the BG-P400-TAT for 48 hours, harvested, and immediately processed for RNA isolation from three biological replicates of control and drug-treated cells. BG-P400-TAT targets among intracellular multiprotein complexes NF-kB complex, Survivin complex, Bcl-2 complex, and VEGF-A complex and integrated with signal transduction pathways of EGF, FGF1, AR, estradiol, TNF, and IL-1 To evaluate the anticancer functions of BG-P400-TAT in SK-N-AS cells, igenome-wide expression profiling experiments were carried out. RNA isolation from two biological replicates of control SK-N-AS cells compared with SK-N-AS cells treated with BG-P400-TAT (30 µM) for 48 h.