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Ectopic recruitment of the CTCF N-terminal domain with two proximal zinc-finger domains as a tool for 3D genome engineering

NIAID Data Ecosystem2026-05-02 收录

三维基因组工程

CTCF蛋白功能

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300308 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-08-16

染色体结构域

CTCF蛋白功能

Topological domains are key architectural building blocks of chromosomes in complex genomes. Their functional importance and evolutionary dynamics are however not well defined. Here we performed comp

NIAID Data Ecosystem110

CTCF is a Barrier for Totipotent-like Reprogramming [ChIPseq]

CTCF蛋白功能

细胞重编程

Totipotent cells have the ability of generating embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with totipotent-like potential was identified within ESC cultures. Thes

NIAID Data Ecosystem30

Ectopic recruitment of the CTCF N-terminal domain with two proximal zinc-finger domains as a tool for 3D genome engineering [RNA-seq]

三维基因组工程

染色质构象操控

We developed a panel of chimeric proteins consisting of either full-length or truncated CTCF fused with programmable DNA-binding module dCas9 and fluorescent tracker EGFP. We found that the recruitmen

NIAID Data Ecosystem10

CTCF loss has limited effects on genome architecture in Drosophila despite critical regulatory functions.

CTCF蛋白功能

基因组调控

Proteins co-purifying with recombinantly purified and N-terminally GFP-3C-tagged CTCF N-terminus (amino acids 1-293) produced in bacteria were identified by incubating the tagged bait with soluble nuc

NIAID Data Ecosystem50

ChIA-PET from AG04449 (ENCSR580MNR)

染色质相互作用

CTCF蛋白功能

CTCF ChIA-PET in AG04449 For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_

NIAID Data Ecosystem30

Ectopic recruitment of the CTCF N-terminal domain with two proximal zinc-finger domains as a tool for 3D genome engineering

资源简介：

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