Age-related epigenetic changes associated with intrinsic CD8 T cell dysfunction

As we age, our immune system weakens, making us more susceptible to infections and cancers, concurrent with reduced responsive to vaccines – this higher vulnerability of older individuals is due to age-related immune decline. Cytotoxic T cells are responsible for fighting viruses and cancer, however, these cells become less effective with age. This thesis characterises a specific group of cytotoxic T cells known as virtual memory T cells. We investigated changes in DNA and proteins that influence ageing and show that these factors contribute to impaired immune responses. By understanding these changes, we hope to find ways to strengthen the immune system in older individuals.