PAK1 is a Therapeutic Target in Acute Myeloid Leukemia and Myelodysplastic Syndrome
收藏官方服务：
资源简介：
PAK1 is a Therapeutic Target in Acute Myeloid Leukemia and Myelodysplastic Syndrome
应用场景：
创建时间：
2015-07-11
相关数据集
Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia [barcode-seq SG12]
Targeting the MYST acetyltransferases are an exciting therapeutic opportunity in acute myeloid leukaemia (AML). Here we define the individual and combined contribution of KAT6A, KAT6B and KAT7, in ran
NIAID Data Ecosystem90
Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia [RNA-Seq]
A hallmark of acute myeloid leukemia (AML) is the inability of self-renewing malignant cells to mature into a non-dividing terminally differentiated state. To better understand how chromatin factors s
干细胞与再生医学数据中心2022-02-20 更新60
Data supporting the publication: Transcriptomic analysis of glycolytic regulation by lncRNAs in acute myeloid leukemia
Acute myeloid leukemia (AML), a high-mortality malignancy, limits the efficacy of traditional therapies due to high heterogeneity. Glycolysis drives AML progression via the tumor microenvironment, but
DataCite Commons2026-03-16 更新50
Aberrant expression of T cell activation markers and upregulation of Tregs in bone marrow and peripheral blood in acute myeloid leukemia patients
T cells’ function and activation and the immunosuppressive effect of regulatory T cells (Tregs) play a pivotal role in the occurrence and progression of acute myeloid leukemia (AML). In this study, we
Mendeley Data2024-06-25 更新80
CARM1/PRMT4 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis
We investigated the role of PRMT4 in normal and malignant hematopoiesis. We found that knockdown of PRMT4 impairs cell cycle progression, induces apoptosis, and downgretulateds E2F target genes in leu
NIAID Data Ecosystem50
