The human gut metaproteome is reservoir for millions of potential immunomodulatory peptides.

In the present work. we have underwent a deeper insight into the signalization mechanism and other metabolic pathways in which one of those peptides is involved. HM14, encoded in an extracellular glycosyl hydrolase of Bifidobacterium longum subsp. infantis. one of the main bifidobacteria present in the gut of breast-fed infants. Examples of many other immunomodulatory peptides are provided