Unravelling the architecture of Major Histocompatibility Complex class II haplotypes in rhesus macaques. Peptide loading genes

The regions in the genome that encode components of the immune system are often featured by polymorphism, copy number variation and segmental duplications. There is a need to thoroughly characterize these complex regions to gain insight into the impact of genomic diversity on health and disease.Here we resolve the organization of complete major histocompatibility complex (MHC) class II regions in rhesus macaques by using a long-read sequencing strategy including the less polymorfic peptide loading genes.