Determination and comparison of the HQ and the revisited HQ.

g a.s./ha: mass of active substance per hectare expressed in grams.µg a.s./bee: mass of active substance per bee expressed in micrograms.ng a.s./bee: nanogram of active substance per bee.E.D.: Experimental Data.LD50: Median Lethal Dose.HQ: Hazard Quotient (field rate (g/ha)/LD50 (µg/bee)).Revisited HQ (exposure (ng/bee)/LD50 (µg/bee)).N.C.: Not Calculated because of the low toxicity of the active substance.DAR EFSA: Draft Assessment Report of the European Food Safety Authority.PED US EPA: Pesticides Ecotoxicity Database of the United States Environmental Protection Agency.aTime at which the LD50 was determined. The LD50 values resulting from the experimental data were calculated at the time corresponding to a stabilized mortality.bFor each active substance, 2 scenarios of exposure are presented: the lowest and the highest homologated application rate.cFor each active substance, the highest and the lowest known LD50 values were compared to the lowest and highest homologated application rates, respectively.dHQ is the ratio between the application rate (g a.s./ha) and the LD50 (µg a.s./bee).eThe exposure was calculated from the application rate (ng a.s./cm2) and the mean exposure surface area determined with the 20 active substances (1.05 cm2/bee).fThe LD50 values from the experimental data were calculated with the BMD software from the US EPA.gThe revisited HQ is the ratio between the exposure (ng a.s./bee) and the LD50 (ng a.s./bee).hFor each active substance, the dose-mortality relationship was modeled at the time corresponding to a stabilized mortality.Determination and comparison of the HQ and the revisited HQ.