Liver transcriptome profiling of liver specific miR-122 knockout and control male mice

Liver transcriptome profiling of liver specific miR-122 knockout (miR-122loxP/loxP Alb-Cre) and control (miR-122loxP/loxP) male mice. Expression profile of several hundred mRNAs that include miR-122 targets were altered in miR-122 KO livers. Loss of miR-122 in the germ line resulted in significant changes in hepatic gene expression profile. Among the upregulated genes many are direct targets of miR-122 GSM517838-GSM517847: Liver transcriptome profiling of liver specific miR-122 knockout and control male mice. Total liver RNA from 8 week old five control and five liver-specific miR-122 knock out male mice (C57/BL6J background) GSM791601-GSM791604: Liver transcriptome profiling of germ-line miR-122 knockout and control male mice. Liver RNA from 5 week old control (floxed) and miR-122KO mice were analyzed by mouse whole transcriptome profiling.本数据集为肝脏特异性微小RNA-122（miR-122）敲除（miR-122loxP/loxP Alb-Cre）雄性小鼠与对照（miR-122loxP/loxP）雄性小鼠的肝脏转录组谱分析数据。miR-122敲除小鼠的肝脏中，包含miR-122靶标在内的数百种mRNA的表达谱发生显著改变。生殖系miR-122缺失会显著改变肝脏基因表达谱，其中上调基因多为miR-122的直接靶标。GSM517838-GSM517847：该组样本为肝脏特异性miR-122敲除与对照雄性小鼠的肝脏转录组谱数据，实验材料为8周龄、C57/BL6J遗传背景的5只对照小鼠与5只肝脏特异性miR-122敲除雄性小鼠的总肝脏RNA。GSM791601-GSM791604：该组样本为生殖系miR-122敲除与对照雄性小鼠的肝脏转录组谱数据，采用小鼠全转录组谱分析技术，对5周龄对照（floxed）与miR-122敲除小鼠的肝脏RNA进行了检测分析。