Distinct structural classes of activating FOXA1 alterations in prostate cancer progression [ChIP-Seq]. Distinct structural classes of activating FOXA1 alterations in prostate cancer progression [ChIP-Seq]

Chromatin binding profiles for FOXA1, AR, and TLE3 in prostate cancer cell lines with different FOXA1 genotypes. Full-length and truncated forms of FOXA1 are distinguished by C-terminal and N-terminal antibodies. Overall design: Mutant relative to wild-type comparisons including CRISPR knockouts, exogeneous overexpression, and endogeneous mutations.