Streptomyces canus strain:C-509 Genome sequencing and assembly. Streptomyces canus strain:C-509

Streptomyces canus ATCC 12647 is a well-established producer of the nonribosomal peptide antibiotic telomycin. Telomycin exerts strong bactericidal activity through an unique mechanism of action against cell wall cardiolipin, a phospholipid dimer often found at the poles and septa. Close examination of canus' considerable biosynthetic clusters reveals the machinery for telomycin alongside numerous active analogues, as well as many other unrelated clusters that may produce active small molecules with unique activity or chemistry.