Rnf43

Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in negative regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; forelimb epidermis; genitourinary system; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in endometrial cancer; gastrointestinal system cancer (multiple); irritable bowel syndrome; lung adenocarcinoma; and villous adenoma. Orthologous to human RNF43 (ring finger protein 43). [provided by Alliance of Genome Resources, Nov 2024]

该基因预测具有激活Fz受体结合活性和泛素化蛋白连接酶活性的功能。参与Wnt信号通路的负向调控及干细胞的增殖调控。预测该基因定位于内质网膜和核被膜。预测在质膜上具有活性。在多个结构中表达，包括消化系统；前肢表皮；泌尿生殖系统；肺；以及下颌下腺原基。该基因的人类同源基因与子宫内膜癌、胃肠道系统癌症（多发性）、肠易激综合症、肺腺癌和绒毛腺瘤有关。与人类RNF43（环指蛋白43）同源。[由基因组资源联盟提供，2024年11月]