Syntheses of Optically Active Trifluoronorcoronamic Acids
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https://figshare.com/articles/dataset/Syntheses_of_Optically_Active_Trifluoronorcoronamic_Acids/3736368
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资源简介：
Syntheses of optically active trifluoronorcoronamic acid 6 and its diastereomer 9 are described. Highly stereospecific and diastereoselective
SN2 cyclization of γ-cyanohydrins 3a and 3b gave cyclopropyl nitriles 4a and 4b. Hydrolysis of the cyano group and deprotection of the amino
group of 4a provide trifluoronorcoronamic acid 6. Hofmann rearrangement of the amide which was generated by hydrolysis of the cyano
group and oxidative cleavage of the aryl ring of 4b to provide trifluoro-allo-norcoronamic acid 9.
创建时间：
2016-08-20
