The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445), lumacaftor (VX-809) and ATP/Mg

The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445), lumacaftor (VX-809) and ATP/Mg Descriptor: (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... Authors: Fiedorczuk, K, Chen, J. Deposit date: 2022-09-15 Release date: 2022-10-19 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378, 2022