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X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

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Protein Data Bank Japan2023-09-06 更新2026-03-21 收录
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X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Ohren, J.F, Pavlovsky, A, Zhang, E. Deposit date: 2008-09-30 Release date: 2008-11-11 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.62 Å) Cite: 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase). Bioorg.Med.Chem.Lett., 18, 2008
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2008-09-30
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