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IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

ChEBI2015-12-12 更新2026-07-12 收录

树突状细胞分化

IL-4/STAT6信号通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-75939 数据链接链接失效反馈

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IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

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创建时间：

2015-12-12

树突状细胞分化

组织特异性免疫

Committed precursors of conventional dendritic cells (pre-cDCs) derived from the common DC progenitor which differentiate into cDC subpopulations in peripheral tissues have been identified, but commit

NIAID Data Ecosystem120

RNA-seq profiling of plasmacytoid and conventional dendritic cells from wildtype and PU.1 knockout mice

树突状细胞分化

转录组调控

Dendritic cells (DCs) are can be broadly divided into conventional (cDC) and plasmacytoid (pDC) subsets. Despite the importance of this lineage diversity, its genetic basis is not fully understood. RN

NIAID Data Ecosystem20

Dendritic cell lineage commitment is instructed by distinct cytokine signals

树突状细胞分化

细胞信号传导

Dendritic cell lineage commitment is instructed by distinct cytokine signals

ChEBI2011-11-13 更新20

Transcriptional profiling of small intestinal lamina propria Dendritic cells by microarray

黏膜免疫

树突状细胞分化

CD103+CD11b+ dendritic cells (DC) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming growth factor receptor 1 (TGF beta 1) has an

NIAID Data Ecosystem40

RNA-Seq of in vitro generated purified cDC1 from c-Jun/JunB fl/fl and c-Jun/JunB Δ/Δ Itgax-Cre mice

树突状细胞分化

转录调控机制

We used RNA-Seq to define genes that control cDC1 indentity in the absence of the transcription factors c-Jun and JunB. FLT3 Ligand-derived cDC1 were generated from murine bone marrow in vitro, sort-p

NIAID Data Ecosystem20

IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

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