Community metrics and functionality from the simulated colon microbiome rebound following sulindac supplementation.. Faecal incubations

We aimed at elucidating how short- and long-term supplementation of sulindac influenced bacterial cell count, community composition and functionality using a dynamic gut model including a mucosal compartment. Faecal incubations were employed to monitor short-term response to clinical concentrations of sulindac and subjects showing opposite fermentation patterns were monitored with the Mucosal Simulator of the Human Intestinal Microbial Ecosystem (M-SHIME) for 6 weeks.