Neural activity in rodent perirhinal and medial agranular cortices in a Go/Delay-Go task

We recorded local field potentials in rodent perirhinal (PER) and medial agranular (AGm) cortices during a two-choice visual discrimination Go/Delay-Go task in which rats discriminated between two images and performed an appropriate motor response to obtain a reward. Rats successfully acquired the Go/Delay-Go task, performing an average of 5±1 blocks of ≥ 5 consecutive correct trials and 10±1 blocks of ≥ 10/12 correct trials in a session. Power spectra, spectrograms, and coherograms revealed differential and coupled local field potential activity between PER and AGm during performance of the task. Mean coherence and phase offset demonstrated coupling in the theta (5-8 Hz), beta (12-25 Hz), and low gamma (30-50 Hz) frequency ranges. Our results indicate that PER and AGm interact during the Go/Delay-Go task during periods of image discrimination, motor and choice planning, and motor initiation.