Aryl hydrocarbon receptor activation alters emergency hematopoiesis during influenza A virus infection

Hematopoietic stem and progenitor cells (HSPCs) produce all cells of the blood and immune system in a process known as hematopoiesis. During infection, there is an increased demand for immune cells, which causes HSPCs to rapidly and transiently modify cellular output, a response described as emergency hematopoiesis. Small molecules from the host environment may contribute to signals that regulate emergency hematopoiesis, providing a means to influence important processes during infection. Environmental exposures have long been associated with altered immune responses in the human population and experimental studies. Specifically, chemicals that bind the aryl hydrocarbon receptor (AHR) modulate immune responses in a broad range of contexts, including during viral infection. Separate studies have shown that AHR signaling also influences steady-state hematopoiesis. Using two different AHR ligands, 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and 2-(1H-indol-3-ylcarbonyl)-4-thiazole-carboxyl..., , # Data from: Aryl hydrocarbon receptor activation alters emergency hematopoiesis during influenza A virus infection

Dataset DOI: [10.5061/dryad.sf7m0cgkz](https://doi.org/10.5061/dryad.sf7m0cgkz)

## Description of the data and file structure

Enclosed are tables of the percentage and number of hematopoietic stem and progenitor cells in the bone marrow of mice, the average percentage and number of platelets, red blood, and monocytes in the blood of mice, and the mean percentage and number of monocytes in the lungs of mice.

### Files and variables

#### File: Data.xlsx

**Description:** Mean percentage and number of hematopoietic stem and progenitor cells in the bone marrow and cells of the blood in mice

##### Variables

* Mice were treated with vehicle-control (peanut oil), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or 2-(1H-indol-3-ylcarbonyl)-4-thiazole-carboxylic acid methyl ester (ITE)*.* The following day, mice were infected with the influenza virus (HKx31, 120HAU). Mice were s...,