The Rfg1 and Bcr1 transcription factors regulate acidic pH-induced filamentous growth in Candida albicans

To investigate the function of Rfg1 in sensing acidic pH and regulating filamentation in C. albicans, we performed the global gene expression profile analysis of WT and rfg1/rfg1 mutant.We reveal that Rfg1 is an essential acidic pH sensor in C. albicans. Rfg1 regulates filamentous growth in acidic pH condition via co-regulation of Rim101-Phr1 pathway, cAMP signaling pathway,and the transcription factors Bcr1, Efg1, Flo8, and Hgc1. Overall design: Comparative gene expression profiling analysis of RNA-seq data for WT and rfg1/rfg1 mutant under acid pH condition