ceRNA-microarray reveals abnormal RNA of tuberculosis in PBMC

RNAs can provide abundant pathological information regarding etiology and could include candidate biomarkers for diagnosis of tuberculosis.Our study focused on RNA expression profiles. The purpose of our study is characterized the RNA profiles of tuberculosis patients and identified significant lncRNAs, circRNA and mRNA associated with tuberculosis as diagnostic biomarkers and treatment target. PBMC from a total of 8 tuberculosis patients and 9 age- and gender-matched Health controls were included high-throughput ceRNA microarray analysis. Tuberculosis patients were diagnosed based on positive Mycobacterium tuberculosis culture, positive Xpert MTB/RIF, positive microscopy, or positive histology. All enrolled HCs were confirmed as not infected with Mycobacterium tuberculosis. All subjects had no other immune system diseases.