a-Synuclein (a-Syn) is a protein implicated in the pathogenesis of Parkinson's disease (PD). It is primarily cytosolic and reversibly interacts with cell membranes. a-Syn also occurs in the nucleus, h
LUHMES cells share many characteristics with human dopaminergic neurons in the substantia nigra, the cells, the demise of which is responsible for the motor symptoms in Parkinson's disease (PD). LUHME
Previously, we showed that cholinergic interneurons of the dorsal striatum lose cilia in mice harboring the Parkinsonâs disease associated, kinase activating, R1441C LRRK2 mutation (Dhekne et al., 2
We analyzed the transcriptomic profile of post-mortem explants from dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra obtained from controls and Braak 4 (BK4) and 5 (BK5) stages of P
