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Heat shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux

Name: Heat shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux
Creator: ShanghaiTech University
Published: 2025-01-20T15:17:46+08:00

integrated proteome resources2026-02-07 收录

神经退行性机制

自噬调节研究

数据链接：

https://www.iprox.cn/page/project.html?id=IPX0010921000 数据链接链接失效反馈

官方服务：

资源简介：

Heat shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux

应用场景：

提供机构：

ShanghaiTech University

创建时间：

2025-01-20

神经退行性机制

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Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology [14 months]

神经退行性机制

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SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration. SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration

神经退行性机制

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We used RNA sequencing of mouse hippocampal tissue two and four weeks after viral-mediated knockdown of SKA2, in order to examine if transcriptional changes might be associated with a hyperactivated s

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Studies of the effects of mutant p97/VCP on human motor neurons.

神经退行性机制

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To uncover the molecular mechanisms that underlie the effects of mutant p97 on human MNs and search for potential treatments, we differentiated iPSCs derived from IBMPFD patients. These cells, which c

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Heat shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux

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