Crystal structure of C. difficile penicillin-binding protein 2 in complex with ceftobiprole

Crystal structure of C. difficile penicillin-binding protein 2 in complex with ceftobiprole Descriptor: (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Penicillin-binding protein, ZINC ION Authors: Sacco, M, Chen, Y. Deposit date: 2021-07-08 Release date: 2022-03-23 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3 Å) Cite: A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile. Nat Commun, 13, 2022