Long noncoding RNAs expression profile in rat extra-synaptic and synaptic NMDAR activation neurons

The study revealed differentially expressed lncRNAs in synaptic and extrasynaptic NMDAR activation and suggested that lncRNAs might be responsible for extrasynaptic NMDAR-induced neurodegeneration Synaptic NMDAR was activated with Bic/4AP treatment. After blocking activated synaptic NMDAR with MK-801, NMDA and Glycine were applied to selectively activate extrasynaptic NMDAR.Cells were thereafter incubated for 6 h for total RNA extraction and lncRNAs were analised