Expression data from monocytes and monocytic myeloid-derived suppressor cells from HNSCC patients and healthy donors [RNA-seq]

A better understanding of the mechanisms that induce and drive human suppressive myeloid cells, such as myeloid-derived suppressor cells (MDSCs) and tolerogenic dendritic cells (TolDCs), stimulates therapeutic approaches that intent to restore the immune balance in patients. Here, we compared gene profiles of in vitro generated and isolated M-MDSCs derived from cancer patients to monocytes isolated from cancer patients and healthy donors. Human monocytes were isolated from healthy donor blood, M-MDSCs and monocytes were isolated from the peripheral blood of HNSCC patients and M-MDSCs were generated in vitro from patient derived monocytes. 14 samples from 5 patients were obtained plus 3 samples of monocytes from healthy donors for a total of 17 samples for which RNA was extracted and sequenced.