Pan-transcriptomic profiling reveals novel transcripts, isomorphs and non-coding RNAs in endemic pathogenic fungus Talaromyces marneffei

This manuscript describes a pan-transcriptomic profile of <i>Talaromyces marneffei</i> performed with the aid of an RNA-seq-based approach, aimed at characterizing the general transcriptome in this human pathogenic fungus, responsible for talaromycosis. Results confirm that ~58.28% of the genes currently annotated in the T. marneffei genome are, in fact, transcribed in vivo and that ~23.6% of them may display alternative isomorphs. Moreover, we identified 585 transcripts that do not match any gene currently mapped in the genome, represented by 7,358 coding transcripts and 211 non-coding RNAs (ncRNAs), including 102 long-non-coding RNAs (lncRNAs).