Translocation of antigenic peptides back to phagosomes via TAP

After processing by the proteasome, some of the oligopeptides could be reinternalized to the phagosome lumen of the same phagosome through the TAP complex probably acquired during ER-phagosome fusion. Guermonprez et al. (2003) tested this model and observed abundant TAP complex in early phagosomes and its reduction over time. Electron microscopy analysis of purified phagosomes also showed the insertion of TAP2 into the phagosomal membrane.

在蛋白酶体处理后，部分低聚肽可能通过在ER-吞噬体融合过程中获取的TAP复合物重新内吞至同一吞噬体的吞噬体腔内。Guermonprez等人在2003年对该模型进行了测试，并观察到早期吞噬体中TAP复合物的丰富性及其随时间的减少。对纯化吞噬体的电子显微镜分析亦揭示了TAP2蛋白插入到吞噬体膜中的现象。