A Simple and Efficient Copper-Catalyzed Procedure for the Hydrosilylation of Hindered and Functionalized Ketones

The catalytic hydrosilylation of highly hindered and functionalized ketones is described. The
combination of inexpensive catalyst precursors, CuCl and NHC·HX (NHC = N-heterocyclic carbene),
leads to a highly efficient reduction mediator for the preparation of silyl ethers from unfunctionalized
and functionalized alkyl, cyclic, bicyclic, aromatic, and heteroaromatic ketones. A series of catalyst
precursors have been structurally characterized and a catalyst−structure activity relationship is
discussed.