Mortality and potential years of life lost attributable to poor glycemic control in Emiratis with diabetes

The aim of this study was to estimate the fraction of deaths and potential years of life lost (PYLL) attributable to non-optimal HbA1c control among Emirati men and women with diabetes in the United Arab Emirates (UAE).
This study was conducted in outpatient clinics at a tertiary care center in Al-Ain, UAE, between April 2008 and September 2018. The sample comprised of 583 adult UAE nationals, aged ≥ 18 years, with diabetes. Non-optimal HbA1c control was defined as HbA1c ≥ 6.5% and all-cause mortality was defined as death from any cause.

At the end of the 9-year follow-up period, 86 (14.8%) participants died. Overall, up to 33% (95% confidence interval [CI], 2% to 63%) of deaths were attributable to non-optimal HbA1c control among patients with diabetes mellitus (DM). Stratified by sex, the adjusted fraction of avoidable mortality was 17% (95% CI, -23% to 57%) for men and 50% (95% CI, 3% to 98%) for women. Both deaths and PYLL attributable to non-optimal HbA1c control were higher in women compared to men.

Up to one-third of all deaths in adult UAE nationals with DM could be attributed to non-optimal HbA1c control.

本研究旨在估算阿联酋迪拜男性及女性糖尿病患者中，因血红蛋白A1c控制不佳所致死亡比例及潜在寿命损失年数（PYLL）。研究于2008年4月至2018年9月期间，在阿联酋阿因的一所三级医疗中心门诊部进行。样本包括583名年龄≥18岁的成年阿联酋公民，患有糖尿病。血红蛋白A1c控制不佳被定义为HbA1c≥6.5%，而全因死亡率则被定义为因任何原因导致的死亡。在9年的随访期末，86名（14.8%）参与者去世。总体而言，高达33%（95%置信区间[CI]，2%至63%）的死亡归因于糖尿病（DM）患者的血红蛋白A1c控制不佳。按性别分层，调整后的可避免死亡率在男性中为17%（95% CI，-23%至57%），在女性中为50%（95% CI，3%至98%）。与男性相比，女性因血红蛋白A1c控制不佳导致的死亡和PYLL均更高。在所有成年阿联酋糖尿病患者中，高达三分之一的所有死亡可能归因于血红蛋白A1c控制不佳。