184 genes targeted sequencing (NGS) of meningiomas.

Meningiomas are the most common tumor of the central nervous system. Although many meningiomas are slow growing, a significant subset of meningiomas have high World Health Organization (WHO) histopathologic grade, including atypical meningiomas (WHO grade 1, 10%-20%) and anaplastic meningiomas (WHO grade 3, 3%-5%), and are prone to local recurrence despite optimal local control. Moreover, there are subsets of patients with WHO grade 1 meningiomas who develop paradoxical recurrences that could not be predicted from histopathologic or clinical features. The goal of this study is going to identify a prognostic gene signature for meningioma recurrence and mortality after resection using using targeted gene sequencing (NGS).