Upstream regulators of the 24 genes down-regulated by RORγt siRNAs or inverse agonists in human Th17 cells were predicted from IPA analysis and the top 20 regulators are shown.

These regulators were ranked by their P values which reflect the enrichment of the 24 genes regulated directly or indirectly by these upstream regulators. The activation status of upstream regulators was determined from the treatment effect on the involved genes and presented as activation z-scores, with positive value for activated status, and negative value for inhibited status.