synthetic methylotroph, methanol assimilation, transcription-replication conflicts

DataCite Commons2025-01-04 更新70

CDK12 prevents MYC-induced transcription-replication conflicts [ChIP-seq]

In order to identify genes and pathways necessary to preserve genome integrity upon Myc over-expression, we conducted a large siRNA-based screen in isogenic lines. We discovered several genes that sup

NIAID Data Ecosystem20

Targeting transcription-replication conflicts is an effective therapeutic principle for MYCN-driven neuroblastoma [ChIP-seq GB]

母细胞瘤靶向治疗

转录-复制冲突调控

Targeting the function of MYC proteins for therapy is a major challenge in tumor biology. MYC proteins are transcription factors that can globally release RNA polymerase II (RNAPII) from core promoter

NIAID Data Ecosystem10

A synthetic methylotroph achieves accelerated cell growth by alleviating transcription-replication conflicts

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A synthetic methylotroph achieves accelerated cell growth by alleviating transcription-replication conflicts

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