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Yeast translational profiling: rcm1 knockout vs. wild-type with oxidative stress

Alliance of Genome Resources2026-08-01 收录

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rRNA甲基化

数据链接：

https://www.yeastgenome.org/dataset/GSE63030 数据链接链接失效反馈

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资源简介：

Rcm1 methylates ribosomal RNA at C2278 and a knockout of this gene induces structural alterations of rRNA and decreased translational fidelity

应用场景：

翻译保真度

核糖体分析

Upon initiation at an AUG start codon, the ribosome must maintain the correct reading frame for hundreds of codons in order to produce functional proteins. Although some sequence elements are able to

NIAID Data Ecosystem90

Additional file 13 of HMGB1 prefers to interact with structural RNAs and regulates rRNA methylation modification and translation in HeLa cells

rRNA甲基化

翻译调控

Supplementary Material 13.

Figshare2024-08-18 更新50

Analysis of rRNA 2'-O-methylation plasticity upon fibrillarin depletion

rRNA甲基化

翻译调控机制

Ribosomal RNAs (rRNAs) are main effectors of mRNA decoding, peptide-bond formation and ribosome dynamics during translation. Ribose 2'-O-methylation (2'-O-Me) is the most abundant rRNA chemical modifi

NIAID Data Ecosystem40

Germline NPM1 mutations lead to altered rRNA 2’-O-methylation and cause dyskeratosis congenita (microarray). Germline NPM1 mutations lead to altered rRNA 2’-O-methylation and cause dyskeratosis congenita (microarray)

先天性角化不良致病机制

rRNA甲基化

We identify nucleophosmin (NPM1) as an essential regulator of 2’-O-methylation on rRNA by directly binding C/D box small nucleolar RNAs (snoRNAs), thereby modulating translation. We demonstrate the im

NIAID Data Ecosystem50

Crystal structure of eukaryotic Fibrillarin with Nop56 N-terminal domain

蛋白质晶体结构解析

rRNA甲基化

Crystal structure of eukaryotic Fibrillarin with Nop56 N-terminal domain Descriptor: Nucleolar protein 56, rRNA 2'-O-methyltransferase fibrillarin Authors: Hoefler, S, Lukat, P, Carlomagno, T, Blanken

Protein Data Bank Japan2024-11-13 更新40

Yeast translational profiling: rcm1 knockout vs. wild-type with oxidative stress

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