Background: Since the high relapse rate is considered to be responsible for the poor survival of stage M neuroblastoma patients, we tested whether the genomic information of bone marrow-derived dissem

NIAID Data Ecosystem60

Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy. Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy

母细胞瘤基因组学

溶酶体靶向

Transcriptome analysis of mRNA samples from Rb/p53-deficient mouse pineoblastomas Overall design: We anlayzed 12 Rb/p53-deleted mouse pineoblastoma, 5 Rb/p53-mutated pineoblastoam, 3 Dicer1/p53-delete

NIAID Data Ecosystem50

Genome-Wide Analysis of Long Noncoding RNA (lncRNA) Expression in Hepatoblastoma Tissues

母细胞瘤基因组学

非编码RNA表达谱

Long noncoding RNAs (lncRNAs) have crucial roles in cancer biology. We performed a genome-wide analysis of lncRNA expression in hepatoblastoma tissues to identify novel targets for further study of he

NIAID Data Ecosystem60

Recurrence in the chemotherapy regimen of bladder carcinoma originates from quiescent epidermoid-like cells

化疗耐药机制

肿瘤复发机制

Cancer relapse upon chemotherapy remains the primary challenge in cancer treatment. By integrating high-resolution CRISPR/Cas9-based evolving lineage tracing with single-cell RNA sequencing in mice, w

NIAID Data Ecosystem50

Paired diagnostic and relapse medulloblastoma sequencing

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