Identification of differentially expressed miRNAs between SW480 and SW620 spheroid cultures [miRNA]

The colorectal cancer (CRC) cell line pair SW480/SW620 is an accepted model to study CRC progression and metastasis formation. Studying miRNA expression differences might allow to uncover molecular mechanisms that underlie metastasis initiation Both cell lines are derived from the same patient, but at different stages of the disease. They might show differences in tumor-initiating cell (TIC) potential. Spheroid cultures of both cell lines were used to specifically look for differences in the TIC compartment of both cell lines. Three technical replicates were used for both conditions.