Investigations into the use of enzyme inhibitors to control drug release for overdose prevention

Pharmaceutical pain killers, particularly opioids, have seen a rise in misuse and accidental overdoses. This thesis provides a new method in creating these medications in attempt to combat this issue. New formulations termed inhibitor controlled-release (ICR) were created which have the ability to prevent drug release as more doses are consumed, thereby lowering the chance of an accidental overdose. This new approach has laid the foundation for further research which has the ability to save many lives and could reduce the risks linked with some pharmaceutical medications.