eMERGE III: Columbia GENIE (Genomic Integration with EHR)

The Columbia GENIE study contributes and shares phenotype and genotype data for individuals who were treated with our healthcare facilities and consented to share their data with dbGaP for scientific discovery. Some of these individuals have kidney or neurological problems and some are healthy volunteers from the Washington Height patient community. The purpose of this NOMAS study is to obtain information about physical features of the brain, carotid arteries, and heart. Some of our patients are pediatric patients with cardiac conditions. The study sample consists of four patient cohorts: Northern Manhattan Study (NOMAS), N=1072 Pediatric Cardiac Genomic Consortium (PCGC), n=374 Caribbean Hispanics with Familial and Sporadic Late Onset Alzheimer's disease (Caribbean Hispanics/AD), n=330 Alzheimer's Disease Sequencing Project (ADSP, n=44) Genetics of Chronic Kidney Disease Study, n=1256 ]]>
Data of the PCGC and two Alzheimer's cohorts are already available through dbGaP prior to the start of this study (phs000571/phs000496/phs000572) and hence are merely referenced here. For the kidney disease cohort, patients with the diagnosis of Chronic Kidney Disease (CKD) and healthy controls were recruited to the Columbia University CKD Bio-bank. For the NOMAS cohort, eligible participants were stroke-free, were 40 years old, and resided for at least 3 months in a Northern Manhattan household with a telephone. ]]>