Characteristics of EH interactors.

Some characteristics of EH-interactors. Additional information is in Table S1.1Human ortholog were identified through NCBI Homologene or by BLAST searches. (-) indicates that no human orthologue is immediately apparent; (*) indicates putative ortholog (best guess).2Previously known interactions between EH-containing proteins and EH-interactors were obtained from Wormbase or by literature search (indicated by the appropriate references). When the EH-containing protein is indicated (e.g. EHS-1), the physical interaction with the interactor has been described; when the gene is indicated (e.g. ehs-1), the genetic interaction between the genes has been described. (**); in the case of TFG-1, an interaction with the SH3 domains of ITSN-1 was described, by Y2H [63], and TFG-1 was identified by mass-spec in anti-ITSN-1 immunoprecipitates [63].3The expression patterns in C. elegans were derived from Wormbase. NS, nervous system; INT, intestine; PHA, pharynx; BWM, body wall muscles; VPC, vulval precursor cells; VPC-de, VPC descendants; HYP, hypodermis; EMBR, expressed during embryogenesis; VM, vulval muscle; RS, reproductive system; EPI, epidermis; N/A, not annotated.4Functional categories were derived from Wormbase, from the Gene Ontology database, from literature data or inferred from functions of the human homologues. END, endocytosis; TRA, membrane and vesicular traffic; UB/DE, ubiquitin system and protein degradation; ACT, actin dynamics; miRNA, miRNA function; MET, metabolism; AP, apoptosis; SIGN, signaling; TRAN, transcription; REPL, DNA replication; REPA, DNA repair; UNKN, unknown. (?) indicates hypothetical function.