Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1
收藏Protein Data Bank Japan2024-01-10 更新2026-03-21 收录
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Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1 Descriptor: (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic acid, Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Dokurno, P, Kotschy, A, Szlavik, Z, Murray, J, Davidson, J, Csekei, M, Paczal, A, Szabo, Z, Sipos, S, Radics, G, Proszenyak, A, Balint, B, Ondi, L, Blasko, G, Robertson, A, Surgenor, A, Chen, I, Matassova, N, Smith, J, Pedder, C, Graham, C, Geneste, O. Deposit date: 2016-08-09 Release date: 2016-10-26 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature, 538, 2016
创建时间：
2016-08-09
