Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis

The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. We found that miR-1204 was significantly increased in both plasma and aorta of elder patients with AAD, and was positively correlated with age. Cell senescence induced the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induced vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop. Chromatin immunoprecipitation DNA sequencing for target genes binding to p53 in miR-1204 overexpressing or control vascular smooth muscle cells.