Additional file 1 of Metagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease

Additional file 1: Table S1. Summary on statistics of the host properties and clinical parameters from the Shanghai and Beijing cohorts. Table S2. Summary of deep whole-metagenomic shotgun sequencing data production of this study. Table S3. Detailed information of data production, assembly, and MAG reconstruction of 715 samples. Table S4. Detailed information of 1303 non-redundant microbial species reconstructed from the fecal metagenomes of this study. Table S5. Detailed information of the 100 most discriminant species in the random forest regression models of the Shanghai and Beijing cohorts. Table S6. Detailed information of 353 ESRD-associated species. Table S7. Detailed information of 1279 ESRD-associated KOs. Table S8. Detailed information of 103 ESRD-associated KEGG functional modules. Table S9. Detailed information of 3,009 ARGs identified in this study. Table S10. Detailed information of 730 KOs that significantly differed in occurrence frequency between ESRD-enriched and HC-enriched Firmicutes species. Table S11. Detailed information of 40 modules that significantly differed in integrity between ESRD-enriched and HC-enriched Firmicutes species. Table S12. Detailed information of 67 gut species with the highest contribution of uremic toxin levels in serum. Table S13. Abundances and statistical test of 353 ESRD-associated species among the CKD patients vs. healthy controls.