Synthesis and Conformational Studies of Dipeptides Constrained by Disubstituted 3-(Aminoethoxy)propionic Acid Linkers
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https://figshare.com/articles/dataset/Synthesis_and_Conformational_Studies_of_Dipeptides_Constrained_by_Disubstituted_3_Aminoethoxy_propionic_Acid_Linkers/3347677
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资源简介：
A series of cyclic compounds with dimethyl-substituted 3-(aminoethoxy)propionic acid linkers have
been prepared as potential β-turn mimics. The desired linkers were prepared from disubstituted
pyrones, which were coupled with dipeptides and then subjected to macrocyclization using
diethylcyanophosphonate to furnish cyclic compounds 1−5. Conformational analysis was carried
out using NMR and X-ray crystallography. All of the five cyclic compounds were found to exist in
type I or type II β-turn conformations.
创建时间：
2016-05-07
